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Heribert Watzke: The brain in your gut
Poziom:
Temat: Nauka i technologia
This technology
made a very important impact on us.
It changed the way our history developed.
But it's a technology so pervasive,
so invisible,
that we, for a long time,
forgot to take it into account
when we talked about
human evolution.
But we see the results of this technology, still.
So let's make a little test.
So everyone of you turns to their neighbor please.
Turn and face your neighbors.
Please, also on the balcony.
Smile. Smile. Open the mouths.
Smile, friendly.
(Laughter)
Do you --
Do you see any Canine teeth?
(Laughter)
Count Dracula teeth
in the mouths of your neighbors?
Of course not.
Because our dental anatomy
is actually made,
not for tearing down raw meat from bones
or chewing fibrous leaves for hours.
It is made for a diet
which is soft, mushy,
which is reduced in fibers,
which is very easily chewable
and digestible.
Sounds like fast food, doesn't it.
(Laughter)
It's for cooked food.
We carry in our face the proof
that cooking,
food transformation,
made us what we are.
So I would suggest that we change how we classify ourselves.
We talk about ourselves as omnivores.
I would say, we should call ourselves coctivors --
(Laughter)
from coquere, to cook.
We are the animals
who eat cooked food.
No, no, no, no. Better --
to live of cooked food.
So cooking is a very important technology.
It's technology.
I don't know how you feel,
but I like to cook for entertainment.
And you need some design
to be successful.
So, cooking is a very important technology,
because it allowed us to acquire
what brought you all here:
the big brain,
this wonderful cerebral cortex we have.
Because brains are expansive.
So as we have to pay tuition fees now.
(Laughter)
But it's also, metabolically speaking, expensive.
You now, our brain is two to three percent of the body mass,
but actually it uses 25 percent of the total energy we use.
It's very expensive.
Where does the energy come from. Of course, from food.
If we eat raw food,
we cannot release really the energy.
So this ingenuity of our ancestors,
to invent this most marvelous technology.
Invisible -- everyone of us does it every day, so to speak.
Cooking made it possible
that mutations,
natural selections, our environment,
could develop us.
So if we think about
this unleashing human potential,
which was possible by cooking and food,
why do we talk so badly about food?
Why is it always do and don'ts
and it's good for you and it's not good for you?
I think the good news for me
would be if we could go back
and talk about the unleashing,
the continuation of the unleashing of human potential.
Now, cooking allowed also
that we became a migrant species.
We walked out of Africa two times.
We populated all the ecologies.
If you can cook, nothing can happen to you,
because whatever you find,
you will try to transform it.
It keeps also your brain working.
Now the very easy and simple technology
which was developed
actually runs after this formula.
Take something which looks like food, transform it,
and it gives you a good, very easy, accessible energy.
This technology affected two organs,
the brain and the gut, which it actually affected.
The brain could grow, but the gut actually shrunk.
Okay, it's not obvious to be honest.
(Laughter)
But it shrunk to 60 percent
of primate gut
of my body mass.
So because of having cooked food,
it's easier to digest.
Now having a large brain, as you know,
is a big advantage,
because you can actually influence your environment.
You can influence your own technologies you have invented.
You can continue to innovate and invent.
Now the big brain did this also with cooking.
But how did it actually run this show?
How did it actually interfere?
What kind of criteria did it use?
And this is actually taste reward and energy.
You know we have up to five tastes,
three of them sustain us.
Sweet -- energy.
Umami -- this is a meaty taste.
You need proteins for muscles, recovery.
Salty,
because you need salt, otherwise your electric body will not work.
And two tastes which protect you --
bitter and sour,
which are against
poisonous and rotten material.
But of course, they are hard-wired,
but we use them still in a sophisticated way.
Think about bittersweet chocolate.
Or think about the acidity
of yogurt -- wonderful --
mixed with strawberry fruits.
So we can make mixtures of all this kind of thing
because we know
that, in cooking, we can transform it
to the form.
Reward: this is a more complex
and especially integrative
form of our brain
with various different elements --
the external states, our internal states,
how do we feel, and so on are put together.
And something which maybe you don't like
but you are so hungry that you really will be satisfied to eat.
So satisfaction was a very important part.
And as I say, energy was necessary.
Now how did the gut actually
participate in this development?
And the gut is a silent voice.
It's going more for feelings.
I use the euphemism digestive comfort.
Actually, it's a digestive discomfort,
which the gut is concerned with.
If you get a stomach ache, if you get a little bit bloated,
was not the right food, was not the right cooking manipulation,
or maybe other things went wrong.
So my story is a tale of two brains,
because it might surprise you,
our gut has a full-fledged brain.
All the managers in the room say,
"You don't tell me something new, because we know, gut feeling.
This is what we are using."
(Laughter)
And actually you use it, and it's actually useful.
Because our gut is connected to our emotional limbic system.
They do speak with each other
and make decisions.
But what it means
to have a brain there
is that, not only the big brain
has to talk with the food,
the food has to talk with the brain,
because we have to learn actually
how to talk to the brains.
Now if there's a gut brain,
we should also learn to talk with this brain.
Now 150 years ago,
anatomists described very, very carefully --
here is a model of a wall of a gut.
I took the three elements --
stomach, small intestine and colon.
And within this structure,
you see these two pinkish layers,
which are actually the muscle.
And between this muscle, they found nervous tissues,
a lot of nervous tissues,
which penetrate actually the muscle,
penetrate the submucosa,
where you have all the elements for the immune system.
The gut is actually the largest immune system,
defending your body.
It penetrates the mucosa.
This is the layer which actually touches the food you are swallowing
and you digest,
which is the lumen.
Now if you think about the gut,
the gut is, if you could stretch it,
40 meters long,
the length of a tennis court.
If we could unroll it,
get out all the fold and so on,
it would have 400 sq. meters of surface.
And now this brain takes care over this,
to move it with the muscles and to do defend the surface
and, of course, digest our food we cook.
So if we give you a specification,
this brain, which is autonomous,
have 500 million nerve cells,
100 million neurons --
so around the size of a cat brain,
so there sleeps a little cat --
thinks for itself,
optimizes whatever it digests.
It has 20 different neuron types.
It's got the same diversity you find actually in a pig brain,
where you have 100 billion neurons.
It has autonomous organized microcircuits,
has these programs which run.
It senses the food, it knows exactly what to do.
It senses it by chemical means
and very importantly by mechanical means,
because it has to move the food,
it has to mix all the various elements
which we need for digestion.
This control of muscle is very, very important,
because, you know, there can be reflexes.
If you don't like a food, especially if you're a child, you gag.
It's this brain which makes this reflex.
And then finally,
it controls also the secretion of this molecular machinery,
which actually digests the food we cook.
Now how do the two brains work with each other?
I took here a model from robotics.
It's called the Subsumption Architecture.
What it means is that we have a layered control system.
The lower layer, our gut brain,
has its own goals -- digestion defense --
and we have the higher brain
with the goal of integration
and generating behaviors.
Now both look -- and this is the blue arrows --
both look to the same food, which is in the lumen
and in the area of your intestine.
The big brain integrates signals,
which come from the running programs
of the lower brain,
But subsumption means
that the higher brain can interfere with the lower.
It can replace,
or it can inhibit actually, signals.
So if we take two types of signals --
a hunger signal for example.
If you have an empty stomach,
your stomach produces a hormone called ghrelin.
It's a very big signal.
It's sent to the brain says,
"Go and eat."
You have stop signals.
We have up to eight stop signals.
At least in my case,
they are not listened to.
(Laughter)
So what happens
if the big brain in the integration
overrides the signal?
So if you override the hunger signal,
you can have a disorder, which is called anorexia.
Despite generating
a healthy hunger signal,
the big brain ignores it
and activates different programs in the gut.
The more usual case
is overeating.
It actually takes the signal
and changes it,
and we continue,
even [though] our eight signals would say, "Stop. Enough.
We have transferred enough energy."
Now the interesting thing is that,
along this lower layer, this gut,
the signal becomes stronger and stronger
if undigested, but digestible, material
could penetrate.
This we found from bariatric surgery.
That then the signal would be very, very high.
So now back to the cooking question
and back to the design.
We have learned to talk to the big brain --
taste and reward, as you know.
Now what would be the language
we have to talk to the gut brain
that it's signals are so strong
that the big brain cannot ignore it?
Then we would generate something
all of us would like to have --
a balance between the hunger
and the satiation.
Now I give you, from our research, a very short claim.
This is fat digestion.
You have on your left
an olive oil droplet,
and this olive oil droplet gets attacked by enzymes.
This is an in vitro experiment.
It's very difficult to work in the intestine.
Now everyone would expect
that when the degradation of the oil happens,
when the constituents are liberated,
they disappear, they go away,
because they [were] absorbed.
Actually, what happens is that a very intricate structure appears.
And I hope you can see
that there are some ring-like structures in the middle image,
which is water.
This whole system generates a huge surface
to allow more enzymes
to attack the remaining oil.
And finally, on your right side,
you see a bubbly,
cell-like structure appearing,
from which the body will absorb the fat.
Now if we could take this language --
and this is a language of structures --
and make it longer-lasting,
that it can go through
the passage of the intestine,
it would generate stronger signals.
So our research --
and I think the research also at the universities --
are now fixing on these points
to say: how can we actually --
and this might sound trivial now to you --
how can we change cooking?
How can we cook
that we have this language developed?
So what we have actually, it's not an omnivore's dilemma.
We have a coctivor's opportunity,
because we have learned over the last two million years
which taste and reward --
quite sophisticated to cook --
to please ourselves, to satisfy ourselves.
If we add the matrix,
if we add the structure language, which we have to learn,
when we learn it, then we can put it back,
and around energy,
we could generate a balance,
which comes out
from our really primordial operation: cooking.
So, to make cooking really
a very important element,
I would say even philosophers have to change
and have to finally recognize
that cooking is what made us.
So I would say, coquo ergo sum:
I cook, therefore I am.
Thank you very much.
(Applause)
